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Open Access Article
International Journal of Cancer Research. 2020; 1: (1) 1; 1-5 ; DOI: 10.12208/j.ijcan.20200001.
广州医科大学
深圳市第二人民医院生物样本库
*通讯作者： 谢妮,单位：深圳市第二人民医院生物样本库；
国家自然科学基金广东省自然科学基金
发布时间: 2020-06-18 总浏览量: 2273
PDF 全文下载 引用本文 收录截图（CNKI-Scholar）
人烟酰胺腺嘌呤二核苷酸（DAN+）依赖的脱乙酰基酶Sirtuins家族，广泛参与了细胞代谢、细胞周期及维持基因组稳态的调控。Sirtuins家族成员通过不同方式参与了对基因组稳态的调控，如：防止DNA损伤并促进DNA修复、组蛋白和非组蛋白靶标的脱乙酰基化等。近年来随着研究的深入，对Sirtuins家族在基因组稳定性调节中的作用有了更深的理解，本文着重对Sirtuins家族在维持基因组稳态调节的最近进展进行回顾和总结。
Human Sirtuins family is an nicotinamide adenine dinucleotide（NAD+）-dependent protein deacetylases, which deeply involved in regulation of cellular metabolism, cell cycle progression and maintenance of genomic stability. Members of Sirtuins are involved in the regulation of genomic homeostasis through different pathways, such as prevent DNA damage and promote DNA damage repair, deacetylate both histone and non-histone targets. With further research, the role of sirtuins family in the regulation of genome stability has been further understood. This paper reviews and summarizes the recent progress of sirtuins family in the regulation of genome stability.
[1] Guarente L. Calorie restriction and sirtuins revisited[J].Genes Dev,2013 27 (19) : 2072-2085.
[2] Jang J, Huh Y J, Cho H J, et al. SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair[J] .Stem Cell Reports,2017 9 (2) : 629-641.
[3] Wang G, Wang F, Ren J, et al. SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells[J].Cell Physiol Biochem,2018 48 (2) : 657-669.
[4] Utani K, Aladjem M I. Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability[J].Nucleus,2018 9 (1) : 261-267.
[5] Ong A, Ramasamy T S. Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming[J].Ageing Res Rev,2018 43 : 64-80.
[6] Ghosh D, Bohr V A, Karmakar P. Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair[J].DNA Repair (Amst),2019 79 : 22-31.
[7] Lin Y H, Yuan J, Pei H, et al. KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair[J].PLoS One,2015 10 (4) : e123935.
[8] Utani K, Fu H, Jang S M, et al. Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability[J].Nucleic Acids Res,2017 45 (13) : 7807-7824.
[9] Yasuda T, Kagawa W, Ogi T, et al. Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites[J].PLoS Genet,2018 14 (3) : e1007277.
[10] Zhang H, Park S H, Pantazides B G, et al. SIRT2 directs the replication stress response through CDK9 deacetylation[J].Proc Natl Acad Sci U S A,2013 110 (33) : 13546-13551.
[11] Onn L, Portillo M, Ilic S, et al. SIRT6 is a DNA double-strand break sensor[J].Elife,2020 9 .
[12] Atsumi Y, Minakawa Y, Ono M, et al. ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient gammaH2AX Foci Formation[J].Cell Rep,2015 13 (12) : 2728-2740.
[13] Mao Z, Hine C, Tian X, et al. SIRT6 promotes DNA repair under stress by activating PARP1[J].Science,2011 332 (6036) : 1443-1446.
[14] Hou T, Cao Z, Zhang J, et al. SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair[J].Nucleic Acids Res,2020 .
[15] Tang M, Li Z, Zhang C, et al. SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair[J].Sci Adv,2019 5 (3) .
[16] Song C, Hotz-Wagenblatt A, Voit R, et al. SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability[J].Genes Dev,2017 31 (13) : 1370-1381.
[17] Rifai K, Judes G, Idrissou M, et al. SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer[J] .Oncotarget,2018 9 (55) : 30661-30678.
[18] Serrano L, Martinez-Redondo P, Marazuela-DuqueA, et al . The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation[J].Genes Dev,2013 27 (6) : 639-653.
[19] Michishita E, Mccord R A, Berber E, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin[J].Nature,2008 452 (7186) : 492-496.
[20] Tasselli L, Xi Y, Zheng W, et al. SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence[J].Nat Struct Mol Biol,2016 23 (5) : 434-440.
[21] Li L, Shi L, Yang S, et al. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability[J].Nat Commun,2016 7 : 12235.
[22] Bao X, Liu Z, Zhang W, et al. Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics[J].Mol Cell,2019 76 (4) : 660-675.
[23] Zhao G, Cheng Y, Gui P, et al. Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment[J].J Biol Chem,2019 294 (2) : 576-592.
[24] Ling H, Peng L, Wang J, et al. Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication[J].Cell Rep,2018 25 (10) : 2851-2865.
[25] Kim H S, Vassilopoulos A, Wang R H, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity[J].Cancer Cell,2011 20 (4) : 487-499.
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