Influence of perioperative blood transfusion on the prognosis of radical bladder cancer patients
围手术期输血对根治性膀胱癌患者预后的影响

摘要

目的 探讨围手术期输血对膀胱癌根治术患者预后的影响。方法 回顾性分析接受膀胱癌根治术的患者41例，其中围手术期输血组27例和未输血组14例，比较两组患者的总生存期、术后肿瘤复发率，术区淋巴结有无肿大转移和有无其他脏器转移并进行预后危险因素分析。结果 输血组和未输血组之间生存分析比较，输血组较未输血组可延长膀胱癌根治术患者的生存期（χ2=7.564，P<0.01）。不同输血量之间预后存在差异性（F=4.497，P<0.01），输血量越大，预后越差。结论 围手术期输血是影响膀胱癌患者预后的独立危险因素；输血量越大，患者的总生存期越短；其影响力度不受其他因素的影响，这为临床上合理输血及适度治疗提供了参考价值。

Abstract

Objective: To investigate the effect of perioperative blood transfusion on the prognosis of patients undergoing radical surgery for bladder cancer.
Methods A retrospective analysis was made of 41 patients who underwent radical resection of bladder cancer, including 27 patients in the perioperative blood transfusion group and 14 patients in the non blood transfusion group. The total survival period, tumor recurrence rate after surgery, lymph node enlargement and metastasis in the operation area and other organ metastasis were compared between the two groups, and prognostic risk factors were analyzed.
Results The survival analysis and comparison between the blood transfusion group and the non blood transfusion group showed that the survival period of the patients with bladder cancer undergoing radical surgery in the blood transfusion group was longer than that in the non blood transfusion group（χ2=7.564,P<0.01）. There were differences in prognosis among different blood transfusion volumes (F=4.497, P<0.01). The larger the blood transfusion volume, the worse the prognosis.
Conclusion   Perioperative blood transfusion is an independent risk factor for the prognosis of bladder cancer patients; The larger the blood transfusion volume, the shorter the total survival time of patients; Its influence is not affected by other factors, which provides reference value for rational blood transfusion and appropriate treatment in clinical practice.